A children's manga series created by Osamu Tezuka (Astro Boy and Kimba the White Lion) that ran from November 1976 till 1979 that was a joint effort with Sanrio. Unico is focused on the titular young unicorn that was separated from his family by The Gods (specifically Venus) due to his ability to spread happiness and love to everybody he encounters and meets. The West Wind is forced to wipe Unico's memories of his friends and himself in order to not get easily spotted by The Gods (Venus in the manga).

The series gained two feature films by Sanrio Animation/Sanrio Film (The Fantastic Adventures of Unico and Unico in the Island of Magic) and a pilot short from 1979 called "Unico Black Cloud and White Feather". He also starred in a 2000 anime short "Saving our Fragile Earth: Unico Special Chapter" and co-starred in the 2005 short "Mr. Pinoko's Forest Adventures".

An upcoming manga series titled "Unico: AWAKENING" was announced Spring 2022 handled by Samuel Sattin and Gurihiru, which re-imagines the entire series. The new manga series will run for a total of 4/5 volumes with the first volume releasing August 6, 2024 accompanied by a guide book and activity book. Unico: Awakening will be published by Scholastic as part of its Graphix Imprint label.