The "No bitches?" meme spawned from a captioned screenshot from the movie Megamind, where the titular character is looking at the screen at an angle with a pitying look, captioned with "No bitches?" It has become used as both comedy and as an insult.
Note that the image doesn't have to say No bitches, but if the image implies the viewer has a lack of something, and the character looks pitying or similar, it should be tagged with this.