There are currently 13 images on the site with a completely blank tag. Here's one of them: https://e621.net/post/show/559852/-2014-clothing-equine-female-feral-friendship_is_m
This seems more like a bug really, but if it is possible to alias nothing, a "" (minus the quotes) -> invalid_tag alias could be a quick fix.
It's not searchable as far as I can tell so it's hard for the users to clean up as it stands.
In case someone edits that post, the problem is caused by a leading space in the tag field:
" 2014 clothing equine female feral [etc...]"
Updated by user 59725