@Chameloshi: Does Fable 2 count? You can just shoot the villain mid-monologue. Or Kalas and Melodia from Baten Kaitos, both of whom you created, one of which has literally everyone as the father?

@kamimatsu: I... Think the Fable 2 boss counts as you killing them, albeit it's a very disappointing kill for you.

I've no idea about the second examples since I've never heard about that game and have no idea what it's about.

@kamimatsu: along with what @Chameloshi said, yes you can kill the villain or the Theif in the game shoots him for you after getting agrivated by his yammering.