101 Dalmatian Street is a British-Canadian animated television series developed by Anttu Harlin and Joonas Utti for Disney Channel and Disney+. It is produced by Passion Animation Studios and Atomic Cartoons and is loosely based on the 1956 novel The Hundred and One Dalmatians by Dodie Smith and its film franchise. It is the second TV series, following 101 Dalmatians: The Series, to be based on the franchise. The series is set almost 60 years after the original 1961 film, 101 Dalmatians.

101 Dalmatian Street centers around a large family of 99 Dalmatian puppies whose names begin with the letter "D", and their parents, Doug and Delilah, the latter of whom is a great-great granddaughter of Pongo and Perdita. They often leave the eldest siblings, Dylan and Dolly, in charge while they are busy at work. The dalmatians live by themselves at 101 Dalmatian Street, located in Camden Town, London in the 21st century, with no human supervision as their owner Dodie Smith, an eccentric billionaire, left them her house and went to live on an island.