I always had trouble going through the thumbnails.
usually they are low-res or just too small for me to see anything.
I found a userscript that's supposed to help, but it stopped working and the user's twitter got deleted (rooshoes).
So, I adjusted it to made it work again.
Per default it creates 200px wide thumbs, increases resolution, plays gif as thumbs and makes webm playable in the thumbnail.
In most cases thumbs are replaced by the /sample/ images if possible.
https://greasyfork.org/en/scripts/392572-e621-thumbnail-enhancer
Updated by randomguy85